Welcome to our Diablo 4 Rogue Poison Flurry Build. In this guide we’ll take you through everything you need to know to create and play this powerful build for yourself. The guide covers Skill Tree, Paragon Board choices, Glyphs, Aspects and more! This build uses an alternative melee skill to Twisting Blades and huge amounts of Poison damage from Poison Imbuement to melt enemies. This particular build leans heavily into heavily poisoning enemies with a flurry of daggers.

Rogue Poison Flurry Build Featured Image

Skill Tree and Paragon Board

For our Diablo 4 Rogue Poison Flurry Build we are using the 5 Rare Glyphs to complement our damage and survivability. Below we will put them in order of which one to level first to last.

  • 1 – (Board #3: No Witnesses) Exploit: We will need the extra radius to reach the required stats. Granting us Damage to Vulnerable targets and the ability to apply Vulnerable to all Targets on first hit.
  • 2 – (Board #5: Leyrana’s Instinct) Combat: We will need the extra radius to reach the required stats. Granting us Core Skill Damage and Energy Cost Reduction.
  • 3 – (Board #2: Deadly Ambush) Bane: We will need the extra radius to reach the required stats. Granting us increased Poison Damage and a 10% chance to double Poison Damage.
  • 4 – (Starting Board) Closer: We will need the extra radius to reach the required stats. Granting us increased damage with Cutthroat Skills and Damage Reduction while using melee weapons.
  • 4 – (Board #4: Cheap Shot) Tracker: We will need the extra radius to reach the required stats. Granting us increased Poison Damage and additional Poison duration.
  • 5 – (Board #6: Exploit Weakness) Control: We will need the extra radius to reach the required stats. Granting us increased Damage to Crowd Controlled targets and granting us increased Damage to Slowed or Chilled enemies. This Damage increase is doubled to Stunned or Frozen enemies.

Class Mechanic: Specializations (Combo Points)

Combo points image for Rogue Poison Flurry Build and other builds

Combo Points is our Specialization of choice in this end-game build. This is due to the usage of Puncture to stack Combo Points, allowing you to make very big burst windows. The burst comes from Flurry spam with Combo Points stacked up – the Unique Dagger, Condemnation assists with this playstyle.

Legendary Aspects

Legendary Aspects are one of the most powerful parts of any build. Below we list the ones used for this Diablo 4 Rogue Poison Flurry Build. Each build has a limited amount of Offensive, Defensive, and Utility Aspects that it can use. Here is a reminder of the slot limitations for Legendary Aspects:

  • Offensive – Amulets, Gloves, Ring, Weapons
  • Defensive – Amulets, Chest, Helm, Legs, Shield
  • Mobility – Amulets, Boots
  • Resource – Rings
  • Utility – Amulets, Boots, Chest, Gloves, Helm, Shield

Aspect Priority

Below you will find the list of Aspects we use and recommend for this build. The Aspects are in order starting from most important to the least. However all the Aspects are worthwhile. You can also check the build planner above for these Aspects:

  • Aspect of Encircling Blades (Offensive)
  • Aspect of Bursting Venoms (Offensive)
  • Edgemaster’s Aspect (Offensive)
  • Aspect of Disobedience (Defensive)
  • Aspect of Might (Defensive)
  • Accelerating Aspect (Offensive)
  • Ravenous Aspect (Resource)
  • Aspect of Corruption (Offensive)
  • Aspect of the Protector (Defensive)

Unique Items

  • Penitent Greaves (Boots) – These boots provide decent stats such as Movement Speed. Penitent Greaves also provides a chilling trail that increases your damage to Chilled enemies and Slows them. Replace Ghostwalker’s with these when possible.
  • Harlequin’s Crest (Helm) – The Harlequin’s Crest is the undisupted best in slot Helm for every build in Diablo 4. The helmet provides you with Maximum Life, Cooldown Reduction, Energy Generation and All Stats. On top of this, the Helm provides +4 Ranks to ALL Skills.
  • Doombringer (1-Handed Sword) – Doombringer is the ultimate push weapon for high tier Nightmare Dungeons. This unique weapon has it all, Core Skill Damage, flat Damage increases, Life on Lucky Hit and a huge 39% increase to Max Life. The unique effect of Doombringer also provides a Shadow Damage AoE explosion that reduces damage done by 20% too! As a result, for the highest tiers of end-game, this weapon is a must for pushing.
  • Condemnation (1-Handed Dagger) – Condemnation is a must-have for this build. The ability to gain an instant full Combo Point meter is incredible. This unique Dagger also provides a huge amount of increased Core Skill Damage.

Malignant Hearts

Malignant Hearts, a new addition to Diablo 4 through the first Seasonal experience act as a huge boost to your build capabilities. As a result, we recommend using the following Malignant Hearts for this build:

  • Creeping Death (Wrathful, Super): Your damage over time effects are increased by 30-40% for each different Crowd Control effect on the target. Unstoppable monsters and Staggered bosses instead take 110-130% increased damage from your damage over time effects.
  • The Calculated (Devious, Utility-World Tier III): After spending 150-200 of your Primary Resource, your next attack Stuns enemies hit for 2 seconds.
  • Trickery (Brutal, Defensive): When you use a Subterfuge Skill, leave behind an unstable Shadow Decoy Trap that Taunts enemies. The Shadow Decoy Trap will explode after 6.0 seconds dealing 680-1020 Shadow damage. Cannot occur more than once every 5 seconds.
  • The Vile Apothecary (Wrathful, Super-World Tier IV): Your attacks have a 5-15% chance to apply all Imbuement effects at 40-50% of normal potency.

Alternative Choices

  • The Dark Dance (Vicious, Offensive-World Tier III): Every 5 seconds while above 60% Life, Core Skills cost 68-51 Life instead of your Primary Resource. Skills that consume Life deal 10-20% increased damage.
  • Prudent Heart (Brutal, Defensive-World Tier III): You become Immune for 2.0-4.0 seconds after you lose more than 20% Life in a single hit. This effect can only occur once every 110 seconds.

Item Affix Priority

flurry rogue
HelmRanks to Poison ImbuementCooldown ReductionMax LifeTotal ArmorAll Stats
ChestDamage ReductionClose Damage ReductionMax Life.Total ArmorDexterity
GlovesRanks to FlurryCritical Strike DamageAttack SpeedCritical Strike ChanceCritical Strike Damage with Imbued Skills
PantsDamage ReductionClose Damage ReductionDamage Reduction from Poisoned EnemiesMax LifeTotal Armor
BootsMovement SpeedEnergy Cost ReductionDamage Reduction while InjuredDodge ChanceAll Stats
AmuletMovement SpeedDamage ReductionCooldown ReductionRanks to MaliceRanks to Weapon Mastery
Ring x 2Critical Strike ChanceCritical Strike DamageVulnerable DamageMax LifeCritical Strike Damage with Imbued Skills
Weapon 1H / 2HVulnerable DamageCritical Strike DamageCore Skill DamageDexterityCritical Strike Damage with Imbued Skills

How to play Poison Flurry Rogue

  • The best way to play this build is to focus on proc windows from your Aspect of Bursting Venoms. This is due to the Bursting Venoms proc leaving a pool of acid that gives you infinite Poison Imbuement activations. Engage with Shadow Step onto a pack, drop your Poison Trap, activate Poison Imbuement and spam Flurry. If you activate your Bursting Venoms Aspect, spam Poison Imbuement between too!
  • Use Dash and Shadow Step as a means of re-positioning.
  • Dash can also be used as a means of dealing increased damage due to the Critical Strike Damage modifier it gives. To make the most of this, build up your Combo Points, Poison Imbuement your Dash, Dash through the enemies and then round off the combo with a Flurry for massive damage.
  • Shadow Step can also be used to Stun priority mobs in any scenario, make sure to assess what is the most dangerous enemy to you or your party and plan based on that.

How to Play vs Mob Packs, Elites and Bosses

  • When approaching single-target fights such as World Bosses or high tier Nightmare Dungeon bosses, there is no real changes you need to make with this build. This build in particular is incredibly powerful against single-target!
  • To get the most out of your damage in large packs of mobs, weave in as many Punctures as possible to build your Combo Points. This allows you to gather up the enemy while applying Vulnerable and building Combo Point stacks. From here, you can drop your Poison Trap, activate Poison Imbuement and spam Flurry.
  • Against Elites, entering the fight by Crowd Controlling the most dangerous target is advised. To achieve this efficiently, use Shadow Step as an engage tool. Soon after Shadow Step is used, you can immediately drop a Poison Trap to knock the Elite down too.

Additional Tips

This particular Rogue build that plays around Poison Imbuement excels in pretty much all content within Diablo 4. However, there is a few important things to note throughout each end-game activity and tweaks to the Skill Tree and Aspects:

  • With a +4 Ranks to Poison Imbuement Helm, you can reach 5/5 on the Imbuement and spread a lot of points into other areas. For example, more points in utility nodes.
  • Close Quarters Combat, our Key Passive can deal huge amounts of bonus damage for us. As a result of this, be sure to keep up a good habit of weaving Punctures and Flurry.
  • In the PVP Fields of Hatred, the Rogue is a formidable and high-speed opponent. For PVP content we recommend switching out Poison Trap to Concealment. Concealment acts as both a surprise engage tool and an unstoppable utility. This Skill can also serve as a burst opener, as one of the perks in the Skill Tree provides a Guaranteed Critical Strike with Flurry or Shadow Step upon Stealth Break.
  • Survivability is key if you are pushing higher tier Nightmare Dungeons. If you are struggling to survive, focus on improving positioning or adding more Damage Reduction sources to your gear and Paragon.
  • In the PVP Fields of Hatred, switching out or hot-swapping gear to have access to the Eluding Aspect to break out of stun-lock, Exploiter’s Aspect to fight Barbarians, Aspect of the Protector to gain a shield vs an opponent and Escape Artist to guarantee Dodge on several attacks – is recommended. Some Aspects gain far less value while fighting in PVP.
  • Always keep an eye on your Bursting Venoms proc! This proc allows for windows of infinite Poison stacking as a result of Bursting Venoms giving Poison Imbuement no cooldown.


This concludes our guide for the Rogue Poison Flurry build in Diablo 4! For more information on Diablo 4, including Class Builds and Guides, be sure to check out our Diablo 4 home page!