Crossbow - Daggers

Greatsword - Dagger

Longbow - Dagger

Longbow - Staff

Staff - Dagger

Crossbow - Staff

Wand - Longbow

Wand - Dagger

COMING SOON

Sword & Shield - Greatsword

Sword and Shield - Dagger

Sword and Shield - Wand

Introduction

The information listed below is obtained from in game. You can find this information by looking at your “Access Info” menu. The below information was compiled in order to have a quick look at how to farm the Python in the First Descendant versus having to navigate the many menus in game.

The abbreviation AMO# stands for Amorphous number. You will need to obtain an amorphous material first. You can do this by farming the “AMO Location” below. Next, go to the AMO Open Location in order to open the amorphous for a chance at receiving the material you’re looking for. The Drop % is the drop percentage chance you’ll have at receiving the material when you open the amorphous.

Any mission that requires Hard mode is highlighted in red and noted with a (H). Normal mode missions are noted with a (N). The locations are listed by zone first and then the area within that zone.

You only need to obtain one of each of the materials in order to craft the weapon. Once you have them you can make your way to Anais in Albion to craft your new ultimate weapon.

You can see where to farm all of the other Ultimate Weapons in the game by checking this guide!

How to Farm the Python

MaterialAMO #AMO LocationAMO Open LocationDrop %
Python Polymer Syncytium29(N) Agna Desert
The Asylum
(N) Devourer
Colossus
6%
Python Polymer Syncytium44AA(N) Hagios
Old Mystery
(N) Swamp Walker
Colossus
15%
Python Polymer Syncytium54(H) Kingston
Fallen Theatre Outpost
(H) Kingston
Grand Square Reactor
32%
Python Polymer Syncytium88(H) Agna Desert
Vermilion Waste Outpost
(H) Agna Desert
Vermilion Waste Void Reactor
32%
Python Nano Tube7(N) Sterile Land
Repository Outpost
(N) Sterile Land
Repository Void Reactor
6%
Python Nano Tube39(N) White-Night Gulch
Block Kuiper Mining
(N) Pyromaniac
Colossus
15%
Python Nano Tube59(H) Kingston
Slumber Valley
(H) Executioner
Colossus
32%
Python Nano Tube102(H) White-Night Gulch
Hatchery Outpost
(H) White-Night Gulch
Hatchery Void Reactor
32%
Python Synthetic Fiber5(N) Kingston
Kingston Defense
(N) Grave Walker
Colossus
38%
Python Synthetic Fiber9(N) Sterile Land
The Forgottense
(N) Stunning Beauty
Colossus
38%
Python Synthetic Fiber96(H) Agna Desert
Caligo Ossuary
(H) Swamp Walker
Colossus
32%
Python Synthetic Fiber105(H) Hagios
The Haven
(H) Obstructer
Colossus
32%
Python Blueprint25(N) Echo Swamp
Defend Albion Resources
(N) Dead Bride
Colossus
6%
Python Blueprint63(H) Sterile Land
The Repository Outpost
(H) Sterile Land
The Repository Void Reactor
32%
Python Blueprint71AA(H) Vespers
The Lumber Yard Outpost
(H) Vespers
The Ruins Void Reactor
32%
Python Blueprint123(H) Fortress
Defense Line Outpost
(H) Molten Fortress
Colossus
32%

You can see where to farm all of the other Ultimate Weapons in the game by checking this guide!